Research

In 1973, almost fifty years ago, two physicians from the University of Washington, Dr. Kenneth Jones and Dr. David Smith, published their research on the effects of maternal alcohol use on the developing fetus. This was the start of awareness of FAS (FASD) in the U.S.*  Since then, there have been hundreds of research articles on FASD published in mainstream journals. A sample of this research, by topic, is listed below.  

*Paul Lemoine MD, a French pediatrician, published the first research on FAS in 1968.

Prevalence of FASD

May PA, et al. Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities. JAMA. 2018 Feb 6;319(5):474-482

Bell, Carl C, et al. Prevalence of Neurodevelopmental Disorders Among Low-income African Americans at a Clinic on Chicago's South Side. Psychiatr Serv. 2015 May 1;66(5):539-42

Nakhoul, Marie R., et al. Fetal Alcohol Exposure: The Common Toll. J Alcohol Drug Depend 2017 Feb:5(1):257

A comprehensive review combining the molecular as well as the gross physiological and anatomical effects of prenatal alcohol exposure.

Chasnoff, Ira, et al. Misdiagnosis and missed diagnoses in foster and adopted children with prenatal alcohol exposure. Pediatrics. 2015 Feb;135(2):264-70

Smith, Vincent, et al. Caring for Patients with Prenatal  Alcohol Exposure: A Needs Assessment. J Popul Ther Clin Pharmacol Vol 24(1):e25-e39; January 27, 2017

"Prenatal alcohol exposure (PAE) is the United States’ most common preventable cause of birth defects and intellectual and developmental disabilities collectively referred to as Fetal Alcohol Spectrum Disorders (FASD). This study was designed to identify gaps in pediatric providers’ knowledge and practices regarding FASD patient identification, diagnosis, management and referral, and to inform needs-based FASD resource development."

Stigma and FASD

Corrigan, Patrick, W. et al. The Public Stigma of Birth Mothers of Children with Fetal Alcohol Spectrum Disorders. Alcohol Clin Exp Res 2017 Jun;41(6):1166-1173. doi: 10.1111/acer.13381

Flannigan, Katherine, et al. Responding to the Unique Complexities of Fetal Alcohol Spectrum Disorder. Front Psychol 2022 Jan 25;12:778471. doi: 10.3389/fpsyg.2021.778471

American Academy of Pediatrics

Screening for Prenatal Alcohol Exposure: An Implementation Guide for Pediatric Primary Care Providers

Genetic Vulnerability of Fetus

Hemingway Astley, Susan J., et al. Twin study confirms virtually identical prenatal alcohol exposures can lead to markedly different fetal alcohol spectrum disorder outcomes - fetal genetics influences fetal vulnerability. Advances in Pediatric Research. 2019;5:23

Concurrent Drug Use and Alcohol Use 

Bakhireva, Ludmila, et al. Prevalence of Alcohol Use in Pregnant Women with Substance Use Disorder. Drug Alcohol Depend.2018 June 01;187:305-310. doi:10.1016/j.drugalcdep.2018.02.025

Jarlenski, Marian, et al. Polysubstance use among US women of reproductive age who use opioids for nonmedical reasons. Am J Public Health. 2017 August; 107(8): 1308–1310

 

FASD 

 Hagan, Joseph Jr., et al. Neurobehavioral disorder associated with prenatal alcohol exposure. Pediatrics2016 Oct;138(4):e20151553

Glass, Leila, M.S. and Mattson, Sarah N. PhD.  Fetal Alcohol Spectrum Disorders: A Case Study. J Pediatr Neuropsychol. 2017 June ; 3(2): 114–135. doi:10.1007/s40817-016-0027-7

Jirikowic,Tracy, et al. Prevalence and patterns of sensory processing behaviors in a large clinical sample of children with prenatal alcohol exposure. Research in Developmental Disabilities. 2020 May;100:103617.doi:10.1016/j.ridd.2020.103617

Astley, Susan, J., et al. The essential role of growth deficiency in the diagnosis of fetal alcohol spectrum disorder.Advances in Pediatric Research. 2016;3:9

Jirikowic, Tracy, et al. (2016) Regulatory Behaviors and Stress Reactivity among Infants at High Risk for Fetal Alcohol Spectrum Disorders: An Exploratory Study. Journal of Mental Health Research in Intellectual Disabilities. 9:3; 171-188. DOI: 10.1080/19315864.2016.1183246

James, Jan  E., et al. Sleep health issues for children with FASD: Clinical considerations. Int J Pediatr. 2010; 2010:1–7

 

McLaughlin, Susan A., et al. Listening Difficulties in Children With Fetal Alcohol Spectrum Disorders: More Than a Problem of Audibility. J Speech Lang Hear Res. 2019 May 21;62(5):1532-1548. doi: 10.1044/2018_JSLHR-H-18-0359

 

Stephen, Julia M., et al. Delays in auditory processing identified in preschool children with FASD. Alcohol Clin Exp Res. 2012;36(10):1720-1727

Kalberg, Wendy O., et al. Early-life predictors of fetal alcohol spectrum disorders. Pediatrics.2019;144(6)e20182141

Rachappa, Mallikarjuna and Nalawade, Triveni. Alcohol, It’s Effect on Dental Structures and the Role of a Dentist. J Alcohol Drug Depend. 2014 Jan;2(4):166. DOI: 10.4172/2329-6488.1000166 

Chen, Maida Lynn, et al. Sleep problems in children with fetal alcohol spectrum disorders. J Clin Sleep Med. 2012 Aug 15;8(4):421-9

Bell, Stephanie H., et al.The remarkably high prevalence of epilepsy and seizure history in fetal alcohol spectrum disorders. Alcohol Clin Exp Res. 2010 Jun;34(6):1084-9

Chasnoff, Ira, et al. Misdiagnosis and missed diagnoses in foster and adopted children with prenatal alcohol exposure. Pediatrics. 2015 Feb;135(2):264-70

Khazan, Olga.When ADHD Isn't What It Seems. The Atlantic. January 15, 2015

(Ira Chasnoff interview)

Jarlenski, Marian, et al. Polysubstance use among US women of reproductive age who use opioids for nonmedical reasons. Am J Public Health. 2017 August; 107(8): 1308–1310

Nutritional Supplementation and FASD (Choline)

Wozniak, Jeffrey R., et al. Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder.J Neurodev Disord.​.2020 Mar 12;12(1):9

"Children who received choline had higher non-verbal intelligence, higher visual-spatial skill, higher working memory ability, better verbal memory, and fewer behavioral symptoms of attention deficit hyperactivity disorder than the placebo group. No differences were seen for verbal intelligence, visual memory, or other executive functions.

These data support choline as a potential neurodevelopmental intervention for FASD and highlight the need for long-term follow-up to capture treatment effects on neurodevelopmental trajectories."

Jeffrey Wozniak PhD 2015 FASD Choline Supplementation Webinar Video

 

Active Study on Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Study (CHOLINE4) 2022

This is a randomized, double-blind controlled trial of choline supplementation in children with Fetal Alcohol Spectrum Disorders (FASD). The study is comparing two administration durations (3 months vs. 6 months) of choline. The primary outcome measures are cognitive measures.

Eligible: Children ages 30 to 72 months

For more information about participating in this study

Jeff Wozniak, University of Minnesota

For more information about previous choline studies

Collaborator:National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Dr. Carl Bell MD

Northeast Conference on Fetal Alcohol Spectrum Disorders 2017 

Colby College, Maine

Dr. Bell presented on the use of choline supplementation in the treatment of FASD, prenatally and in early childhood.

Jacobson, Sandra, et al. Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Alcohol Clin Exp Res. 2018 Jul;42(7):1327-1341

Kable, J.A., et al.The Impact of Micronutrient Supplementation in Alcohol Exposed Pregnancies on Information Processing Skills in Ukranian Infants. Alcohol 2015 Nov;49(7):647-656

Coles, Claire D., et al. Dose and Timing of Prenatal Alcohol Exposure and Maternal Nutritional Supplements: Developmental Effects on 6-Month-Old Infants. Matern Child Health J. 2015 Dec;19(12):2605-14

Adults with FASD

NIH/NIAAA Current Study 

Fetal Alcohol Spectrum Disorders (FASD) in Adults: Health and Behavior

Principal Investigators: Claire Coles, Ph.D. (Emory University, Atlanta, Georgia), Therese Grant Ph.D. (University of Washington, Seattle, Washington)This current NIH/NIAAA-funded research addresses the deficit of research on adults with FASD with the following Specific Aims: 1) Establish a registry of 500 individuals, older than 30 years of age, with known alcohol exposure/FASD diagnosis or who are matched controls who will respond to a health survey, and who will be available for future studies; 2) Evaluate in depth current physical health, mental health, and functional status among affected individuals (FAS or FASD) and controls (120 from Seattle and 120 from Atlanta);  with the goal of refining diagnostic criteria for FASD in this age group and determining the persistence and severity of disability associated with PAE. and 3) Assess immune status in collaboration with Dr. Weinberg (University of British Columbia) and identify outcomes associated with health indicators. 07/01/17 through 06/30/22

Advances in Research on Fetal Alcohol Spectrum Disorders.NIAAA Spectrum Fall 2020 12(3)

FASD  Interventions

Carmichael Olson, Heather and Montague, Rachel A. An Innovative Look at Early Intervention for Children Affected by Prenatal Alcohol Exposure. Prenatal Alcohol Use and FASD: Diagnosis, Assessment and New Directions in Research and Multimodal Treatment, 2011, 64-107

Paley, Blair, Ph.D, O'Connor, Mary J. Ph.D. Behavioral Interventions for Children and Adolescents With Fetal Alcohol Spectrum Disorders. Alcohol Res Health. 2011; 34(1): 64–75

Petrenko, Christie L. M. PhD. Positive Behavioral Interventions and Family Support for Fetal Alcohol Spectrum Disorders. Curr Dev Disord Rep. 2015 Sep; 2(3): 199–209

Jirikowic,Tracy, et al.Children and Youth with Fetal Alcohol Spectrum Disorders: Summary of Intervention Recommendations after Diagnosis. Intellect Dev Disabil. 2010 Oct;48(5):330-44

Petrenko, Christie L. M., et al.The Association Between Parental Attributions of Misbehavior and Parenting Practices in Caregivers Raising Children with Prenatal Alcohol Exposure: A Mixed-Methods Study. Res Dev Disabil. 2016 Dec;59:255-267

Caregivers who attributed their child's misbehavior to underlying neurodevelopmental disabilities were more likely to use antecedent strategies and feel more confident in managing their child's behavior. Parents who attributed their child's misbehavior to willful disobedience were more likely to rely on consequence strategies and feel more ineffective.”

Occupational Therapy

Jirikowic, Tracy L. et al. Prevalence and Patterns of Sensory Processing Behaviors in A Large Clinical Sample of Children with Prenatal Alcohol Exposure. Research in Developmental Disabilities 2020;(100) 105617

Fjeldsted, Brenda and  Xue, Lin. Sensory Processing in Young Children with Fetal Alcohol Spectrum Disorder. Phys Occup Ther Pediatr2019;39(5):553-565

Franklin, Laureen, et al. Children with Fetal Alcohol Spectrum Disorders: Problem Behaviors and Sensory Processing. Am J Occup Ther​. May-Jun 2008;62(3):265-73